Acute effects of lysergic acid diethylamide (LSD) on resting brain function

The paradoxical psychological effects of lysergic acid diethylamide (LSD).

BACKGROUND Lysergic acid diethylamide (LSD) is a potent serotonergic hallucinogen or psychedelic that modulates consciousness in a marked and novel way. This study sought to examine the acute and mid-term psychological effects of LSD in a controlled study. METHOD A total of 20 healthy volunteers participated in this within-subjects study. Participants received LSD (75 µg, intravenously) on on...

Stereospecific binding of D-lysergic acid diethylamide (LSD) to brain membranes: relationship to serotonin receptors.

D-[3H]LSD binds saturably, reversibly, and with a high affinity (KD = 10 nM) to rat brain membranes. The association and dissociation rates of binding are temperature dependent and fastest at 37 degrees C. Binding is enriched in crude microsomal (P3) membranes. D-[3H]LSD binding is stereospecific as L-LSD, the psychotropically inactive enatiomer, is 1000 times weaker than D-LSD as a displacing ...

Lysergic acid diethylamide: side effects and complications.

Effect of lysergic acid diethylamide (LSD-25) on morphine induced bradycardia.

Several antagonistic interactions between morphine and LSD-25 (lysergic acid diethylamide) have been demonstrated. LSD-25 antagonizes morphine induced analgesia in rats (1) and emesis in dogs (2). It also blocks the miotic action of morphine (3). On the other hand morphine blocks LSD-25 induced pyre xia in rabbits (4) and the central hypotensive effect of LSD-25 in dogs (5). Morphine produces m...

Lysergic Acid Diethylamide: Its Effects on a Male Asiatic Elephant.

A saline pond in a region in Antarctia where other lakes and ponds are frozen remains unfrozen at the prevailing low temperatures. The ecology of the pond is unique. A distinctive aerobic microbial population, though restricted to this natural habitat, adapts to growth in artificial culture. The growth habit of these organisms, as seen in nature and in laboratory culture, indicates a possible r...